Background: The development of accurate protein-protein docking programs is making this kind of simulations an\r\neffective tool to predict the 3D structure and the surface of interaction between the molecular partners in\r\nmacromolecular complexes. However, correctly scoring multiple docking solutions is still an open problem. As a\r\nconsequence, the accurate and tedious screening of many docking models is usually required in the analysis step.\r\nMethods: All the programs under CONS-COCOMAPS have been written in python, taking advantage of python\r\nlibraries such as SciPy and Matplotlib. CONS-COCOMAPS is freely available as a web tool at the URL:\r\nhttp://www.molnac.unisa.it/BioTools/conscocomaps/.\r\nResults: Here we presented CONS-COCOMAPS, a novel tool to easily measure and visualize the consensus in\r\nmultiple docking solutions. CONS-COCOMAPS uses the conservation of inter-residue contacts as an estimate of the\r\nsimilarity between different docking solutions. To visualize the conservation, CONS-COCOMAPS uses intermolecular\r\ncontact maps.\r\nConclusions: The application of CONS-COCOMAPS to test-cases taken from recent CAPRI rounds has shown that it\r\nis very efficient in highlighting even a very weak consensus that often is biologically meaningful.
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